Extensive research, led to the understanding that small noncoding miRNAs played an important role in fine-tuning the genome. Complex networks in the brain are formed by the usage of transcriptome in wide range of combinations. Modulation of expression of thousands of genes is achieved by specific miRNAs controlling the target mRNA expression, leading to various physiological processes. Primary transcripts of miRNA are synthesised by RNA polymerase from miRNA genes. These transcripts are processed in the nucleus by the Drosha enzyme to produce a hairpin-like precursor miRNA (premiRNA).

Menarini Asia-Pacific is just over a decade old, having established its regional headquarters in Singapore back in November 2011. Over the past decade, the island-nation’s positioning has changed from just a pharmaceutical manufacturing outpost to an international biomedical hub that encompasses the entire innovation and manufacturing value chain.

Globally, there remains an unmet need for advanced research in healthcare biotechnology and diagnostics. Singapore’s reputation for quality research and development (R&D), supportive operating environment, and talent pool made it an easy decision

The cyber-physical security of any manufacturing system, specifically food and drug manufacturing, is essential. The technology in the pharmaceutical industry advanced significantly in last decade to improve upon every aspects of drug manufacturing. However, much less attention has been paid to identify and proactively mitigate the risk of cyber-physical attacks. Viruses that threaten these systems are very real and in recent years have proven very harmful and costly. Those that target drugs consumed by billions of people worldwide will inevitably have deadly consequences. Even with dedicated

The global pharmaceutical industry is currently facing many, wide ranging, challenges, including an aging population, increased life expectancy, a rise in chronic conditions, reduced funding for treatments, reduced numbers of clinical staff, the ever increasing cost of drug development and raw materials, and supply chain issues. Consequently, the pharmaceutical industry is increasingly looking at how a wealth of data, including compound libraries, trial data, and patient data, can be used and reused by artificial intelligence (“AI”) to alleviate these challenges and improve patient care.

There's a need consolidate natural information with computational strategies for extricating important and fitting qualities from the thousands of qualities measured. Artificial Intelligence (AI) has been connected within the sedate disclosure field for decades. Today, conventional machinelearning modelling has advanced into an assortment of unused strategies, such as combi-QSAR and crossover QSAR, and remains a prevalent approach to consider different drug-related themes. There are different drugs on the showcase and/or in clinical trials that have been outlined by computational strategies.

Artificial Intelligence (AI) and machine learning-based technologies have the potential to transform healthcare because they offer new and important insights derived from the vast amount of data generated during the delivery of healthcare every day. The capacity of AI to learn from real-world feedback and improve its performance makes this technology uniquely suited as Software as a Medical Device (SaMD) and is responsible for it being a rapidly expanding area of research and development. Clinical pharmacy practice may undergo major change due to the implementation of this technology. The cha

Genomic medicine — the therapeutic use of cells and genetic materials — is at the center of a medical revolution. Approvals of genomic medicines are growing each year, fueled by new precision medicine platforms that target diseases without current effective treatments. Viral vectors, primarily adeno-associated virus (AAV), efficiently treat some diseases caused by monogenic mutations. Gene-modified cell therapies, notably CAR-T cell therapies, successfully treat some late-stage blood cancers but face obstacles for use with solid tumors. Challenges remain for both cell and gene therapies, incl

The sterile pharmaceutical market is expected to expand significantly in the coming years due to the increasing demand for biological drugs, Advanced Therapy Medicinal Products (ATMPs)/Cell and gene Therapies (CGTs), and generic sterile injectable. The global sterile manufacturing market is projected to grow by more than 50% by 2028. Developing advanced aseptic manufacturing techniques has improved sterile injectable drugs' quality, safety, and shelf-life, contributing to market growth. However, challenges such as the shortage of sterile-manufacturing talent and regulatory GMP compliance may

Advanced continuous manufacturing (CM) is emerging as a preferred platform to produce full finished injectable liquid dosage forms. In this work, a novel plant and digital twin model of continuous manufacturing of full finish final liquid dosage forms has been developed. The developed continuous injectable manufacturing process takes the API synthesized and purified via a continuous API manufacturing process, either in powder form or as a solution in the final liquid ingredient of the formulation and turns it into a finished liquid product. This process is composed of three flexible modules t

Mass spectrometry (MS) has become an indispensable tool during manufacturing process development, also known as CMC (Chemistry Manufacturing and Controls) development, for biologics. Information about product-related variants (such as post-translational modifications (PTMs)) and process-related impurities (such as host cell proteins (HCPs)) can be extensively characterized by MS to understand process performance and product quality. The in-depth data provided can play a key role in defining and understanding the Critical Quality Attributes (CQAs) which need to be well-controlled by the manufa

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Traumatic events such as date rape, drowning or death of loved ones in accidents often necessitate the use of antidepressants for a short treatment course. Unfortunately, many antidepressant use is plagued by antidepressant discontinuation syndrome (ADS). ADS is a common problem in patients following the interruption, dose reduction, or discontinuation of antidepressant drugs. Typical symptoms of antidepressant discontinuation syndrome include extreme insomnia, nausea, gait instability, sensory disturbances, dizziness, increased suicidal thoughts and hyperarousal. These symptoms can be disabl

The reverse engineering of an RLD—product deformulation—is a critical step in the development of more accessible and less expensive generic versions. Deformulation relies on analytical technologies to not only tease apart the physicochemical properties of an innovator drug and its constituent parts—its active pharmaceutical ingredients (APIs) and excipients—but also offer drug developers insights into how the innovator RLD was manufactured. Such information is vital to drug companies competing to develop generic alternatives as drug products approach or pass patent expiration.

Despite all recent advances of molecular biology and imaging techniques, treatment designs based on pharmaceuticals still need enhancement to improve prognostics of patients while reducing the severity of side effects. The development of DNA sequencing techniques enabled an unprecedented increase of our understanding of genetic diseases such as cancer [1]. Cancer sub-types classification based on specific mutations, such as the mutation of Epidermal Growth Factor Receptor (EGFR) gene related to lung cancer, increased prognostic accuracy while providing the opportunity for early interventions.

Before diving into the ocean of Indian scenario for biologics, let’s get some basics right.

The question which confuses people many a times is: are generics and biologics the same? And the answer is no, they are not the same. Let’s find out how.

Biologics are basically the products which are developed and produced from living organisms like human, plant or animal cells and, of course, microorganisms (bacteria, yeast, etc.). Having no definite structure, biologics are large and complex molecules which undergo sophisticated procedures while being developed and manufactured. Monoclonal ant

Having fixed interest rates will lead to paying more money.

Debt reduction, house improvement, car purchase and holidaying are some of the most popular uses how the unsecured loan proceeds shall be utilized in. These lenders, no matter how big they are, want as much guarantee as possible.

This money is mostly used by banks in discharging its services such as lending loans.
All in all, even though there are a few steps you have to follow and proof that you need to gather, you will still often be able to get a loan despite your credit.

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