Seoochre

Cannabis plants contain a wide variety of complex compounds including phytocannabinoids, terpenoids and flavonoids, found mainly in the inflorescences. Major phytocannabinoids like CBD and ∆9-THC have beneficial effects on human health. It is well known that variations in their profiles are connected to growth, light quality, humidity, the use of pesticides, harvesting and especially post-harvesting, like improper drying procedures that can facilitate fungal and microbial growth. Mass spectrometry is the tool of choice for the analysis of all these biologically active compounds along with tha

COVID-19 infection affecting every one of us from last one year and continue to affecting so far through various new strains. Recently, new variant i.e.Omicron of COVID-19 is emerged and start spreading across the globe.The major objective today is to save the patients as we can from lethal effect of this virus. Reports have shown the massive increase in various inflammatory mediators of COVID-19 patients resulting in cytokine storm and death. Steroids are well known powerful anti-inflammatory agents available in the market for the management of various diseases. Thus, use of steroids in COVI

The drug is most many times a natural small molecule that activates or inhibits the feature of a biomolecule such as a protein, which in flip results in a therapeutic gain to the patient. In the most fundamental sense, drug diagram entails the graph of small molecules that are complementary in form and cost to the biomolecular goal with which they engage and consequently will bind to it. Drug sketch often but now not necessarily relies on laptop modeling techniques. This kind of modeling is frequently referred to as computer-aided drug design. Finally, drug layout that relies on the expertise

Cancer treatment has traditionally relied on surgery, chemotherapy, and radiation therapy. However, recent advancements have led to the emergence of targeted therapy and immunotherapy as new dimensions in cancer treatment. Immunotherapy focuses on boosting the patient's immune system to fight cancer, with immune checkpoint inhibitors as the foundation. CAR-T cell therapy, which genetically modifies T-cells to target specific cancer cells, has gained substantial interest but are extremely costly. NexCAR19, developed by IIT Bombay under ImmunoAct, is India's first indigenous anti-CD19 CAR-T cel

CIS are syringe-like cell-puncturing machines. Bacteria deploy it for various natural functions including cell-cell communications, defence, and in endosymbionts to interact with the hosts. CIS translocate effectors molecules (toxins or proteins) into the target cell by puncturing its cell membrane. Within the target cell, effectors modulate cell components such as cytoskeleton and DNA.

CIS can be assembled on the cytoplasmic membrane and act as contact dependent system, known as Type VI secretion systems (T6SS). It can exist as free complexes in the cytoplasm, and is released into the ext

This Biopharmaceutics introduces fundamental concepts, methods, and advances in the areas of dissolution, absorption, and permeability and their key applications in dosage form performance. Case studies are used to discuss the applications of biopharmaceutic strategies in the development of successful drugs, with a specific focus on the applications of biopharmaceutic strategies in the development of successful drugs. The book presents an integrated view in linking pharmaceutic to the biological consequences of drug products and leverages those for decision making in drug development. The Bio

To date, the current available drugs or treatments can only delay the progression of the kidney disease yet cannot reverse the progression into the end-stage kidney disease. There has been no significant breakthrough in the medical treatment of kidney diseases. The current therapeutic choices to prolong the lifespan of patients with end-stage kidney disease are limited to kidney replacement therapies, such as dialysis and organ transplantation. Due to the high medical cost involved in dialysis therapy, it is is not an ideal solution because it fails to restore or substitute all kidney functio

In the absence of an effective nanocarrier vehicle, traditional cancer treatment, tumor imaging, and immunotherapy remain ineffective. Artificial liposomes have been used to encapsulate bioactive compounds and release the payload continuously and stimuli-responsively, but they suffer from multiple drawbacks. Extracellular vesicles (EVs) are natural endogenous macromolecule transporters used for drug delivery, but adequate and repeatable loading of the EVs with therapeutic or imaging agents still limits their application as drug delivery systems. EV-liposome hybrids are a novel nanocarrier pla

Biological markers or the more commonly used term ‘Biomarkers’ was first heard of in the 1950s. In the coming years, this term gained unprecedented popularity as myriad studies were carried out regarding the efficacy of biomarkers in the drug discovery and development process as well as in the medical diagnosis of diseases. However, the use of biomarkers is not limited to solely these two fields; chemistry, geology, and astrobiology are only a few of the other domains in which the term ‘biomarker’ makes an appearance.

Over the years, the Food and Drug Administration (FDA) has approved a pl

The drug business has various strange qualities that make it very different from individuals' thought process of as industry. Its additionally an industry packed with logical inconsistencies; for instance, notwithstanding the undisputed reality that for more than a century the business has made a major contribution to human prosperity and the decrease of chronic sickness and suffering, it is still routinely recognized bygeneral society in assessment reviews as one of the most un-confided in ventures, frequently being contrasted horribly with the atomic business. It is without a doubt perhaps

It’s been nearly two years since the outbreak of COVID-19 began and we’re still in the midst of enormous disruptions to the world’s economies, businesses, education, and people’s lives. The pharmaceutical industry has been particularly disrupted. Previously, pharma companies suffered from a bad reputation. But following the emergence of the pandemic, they were thrown into the spotlight, suddenly having an important voice on the health of the world. Leaders in the pharma space were on the front cover of every newspaper and magazine not because of scandal, but because of the lifesaving treatmen

In current drug development, we are educated and trained to follow identical development strategies that have been proven to be successful in the past and assume a guaranteed success for the future. However, as we see with the stock market, past successes do not guarantee anything for the future and a case-by-case customized approach is essential. For example, consider the biology around IgA-IgA receptor (CD89 or FcαR1) interaction in which there are significant differences in species. Ample information has been published over the last 3 decades to show that levels and appearance of autoantig

Drugs as small- or medium-sized molecules (1-2 nanometer in diameter) typically possess both lipophilic and hydrophilic properties. For a drug molecule to reach its intracellular target, it usually needs to cross several barriers including mucus gel layer, intestinal epithelial cells, capillary endothelium, and finally membrane of target cells. In all those interfaces, lipoidal diffusion and protein-mediated passive transport across lipid bilayers play an important role in its molecular entry. Thus, understanding the mechanism of drug transport at biological membranes provides us with a theor

There are many potential benefits that can be derived from IT outsourcing. Apart from cost savings, access to resources is also a driving force behind the outsourcing phenomena. With the right outsourcing partner enabling a flexible allocation of resources, IT projects can be scaled rapidly and affordably. Success or failure of outsourcing often has less to do with the provider and more to do with the customer. This is because discovery R&D organisations are rarely equipped to manage IT and have great difficulty specifying and implementing their goals. If any organisation has a poor track rec

The pharmaceutical industry is in the midst of fundamental changes. The changes have been brought on by the increasing concerns over expiry of patents for major blockbuster drugs, weak product pipelines, heightened awareness of drug safety, globalisation, competition from generics and growing value considerations with regards to access to and reimbursement of new speciality therapeutics. These issues, and more, have forced top pharmaceutical companies to change their current course, in search of a stable and sustainable path that can help them maintain and improve their current profitability

Functional service has been ranked high among the buzz words of the clinical research industry. Both sponsor organisations and service providers are equally excited about the opportunities this model offers and the potentially win-win situation it provides to them. Sponsor organisations typically send individual protocol-related service RFPs (request for proposals) to CROs and follow-up with contract negotiations. Sponsors have realised the benefits of reduced oversight and contract management a complete functional service outsourcing model offers saving valuable time and resources. Depending

The pharmaceutical market in Asia has undergone a paradigm shift in the past few years. The major global pharmaceutical companies have shifted their focus to this region to drive their revenue growth. Moreover, the domestic companies in Asia are also actively participating in the global drug development process. At present, the pharmaceutical market in the region is challenging due to changes in the competitive landscape, increasing R&D costs, and the need to develop the right marketing strategies.

In 2005, the pharmaceutical market in Asia was estimated to be around US$ 21 billion and is

In the ever-evolving realm of pharmaceutical research and development (R&D), the powerful wave of digitalization is restructuring conventional methodologies and paving the way for a novel era of ingenuity and streamlined processes. Termed digital transformation, this profound shift entails the strategic infusion of cutting-edge information technologies into established drug discovery and development procedures. Leading this revolution are technologies like big data analytics, artificial intelligence (AI), blockchain, and telemedicine. Digital transformation signifies a potential revolution in

The top five drivers of this move to sustainability, according to the Packaging Sustainability: A Changing Landscape report from PMMI, The Association for Packaging and Processing Technologies, include brand perception, competitive pressure, environmental advocates, top-down company culture and good stewards of the planet. While a major focus for many, nearly two out of three brand owners participating in the PMMI report cited added cost as the top reason their sustainable packaging initiatives have slowed.

While the package is a vital part of any sustainability strategy, how the product g

The manufacturing process of pharmaceuticals has progressed from batch process to continuous process and now to printing.3D printing technology started gaining increased attention in the pharmaceutical field after the USFDA approval of the first 3D printed pill Spritam® by Aprecia Pharmaceuticals in 2015. This technology has been utilized for the printing of medical devices, dental implants, artificial organs, research prototypes, tailored dosage forms, drug fabrication, and specialty surgical instruments. It offers great flexibility which justifies its use in a wide range of settings includi